Senior Scientist

Senior Scientist

Oxford

Talentmark is partnering with an biotech start-up developing next-generation gene therapies for severe genetic diseases. With a highly collaborative scientific team and innovative platform technologies, the company is advancing cutting-edge preclinical programmes focused on delivering transformative therapies to patients with high unmet need. This is a site-based position located at Oxford.

As part of their continued growth, they are seeking a Senior Scientist with a strong track record of managing outsourced pre-clinical studies within the biotech industry.

This is an excellent opportunity for someone who enjoys working in a fast-paced, science-driven environment where they can combine scientific leadership, CRO oversight, and hands-on laboratory expertise.

The Opportunity

You will play a key role in driving preclinical in vivo studies through external CRO partnerships, supporting the progression of gene therapy programmes from discovery through translational development.

The successful candidate will bring proven experience managing CROs, overseeing in vivo studies, and hands-on wet lab experience collaborating cross-functionally within a biotech setting.

Key Responsibilities

• Lead the design, oversight, and interpretation of preclinical in vivo studies with external CRO partners
• Manage CRO relationships across study planning, timelines, budgets, protocol review, and data delivery
• Act as the internal scientific lead for animal model studies including efficacy, biodistribution, and toxicology
• Maintain hands-on involvement in molecular and cellular biology workflows
• Support the design and optimisation of gene expression constructs and vector development activities
• Contribute to data analysis, project planning, and scientific reporting across multiple programmes

Background:

• PhD in Molecular Biology, Gene Therapy, Immunology, Virology, Translational Medicine, or related discipline
• Proven biotech industry experience within preclinical or translational research environments
• Strong track record managing CRO-based in vivo studies
• Experience with histology, bioanalysis, or biodistribution studies
• Experience driving study execution to timelines
• Hands-on wet lab expertise in molecular and/or cell biology
• Strong scientific data interpretation and problem-solving skills
• Excellent project management abilities

• Experience within gene therapy, viral vectors, or advanced therapeutics
• Exposure to GLP toxicology or IND-enabling studies
• Background working with translational animal models

It is essential that applicants hold entitlement to work in the UK. Please quote job reference 187 510 in all correspondence.